Granulation converts fine powder blends into granules — larger, free-flowing aggregates that are easier to compress into tablets. The choice of wet vs. dry granulation significantly impacts product quality, equipment investment, and production costs.
Wet Granulation
Wet granulation uses a liquid binder to agglomerate the powder blend. The process involves:
1. Dry mixing of API and excipients
2. Addition of granulating liquid (water, ethanol, or binder solution)
3. Wet massing in a high-shear granulator
4. Wet sieving
5. Drying (typically in a fluid bed dryer)
6. Dry sieving and blending with lubricant
Advantages
Disadvantages
Dry Granulation
Dry granulation uses mechanical pressure to compact the powder without any liquid. The two main methods are:
Advantages
Disadvantages
Which Is Right for Your Product?
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GentlemanPharmed supplies both high-shear wet granulators and roller compactors, as well as integrated granulation line solutions.